Anti-Inflammatory Activity of Calendula officinalis L. Flower Extract

The use of calendula for its lenitive properties’ dates to the XII century. This plant contains several bioactive compounds, including terpenoids, terpenes, carotenoids, flavonoids and polyunsaturated fatty acids. Calendula flower extract is used in soothing cosmetics, such as after-sun, sensitive skin eye contour products. anti-inflammatory properties this ingredient were demonstrated an animal model, but mechanism action poorly understood. Therefore, our work explored effect a on NO production, pro-inflammatory radical produced by nitric oxide synthase (iNOS) highly released innate immune cells inflammatory-related pathologies. production was evoked Toll-like receptor 4 agonist lipopolysaccharide (LPS) macrophages, using concentrations that did not compromise viability. exhibited dose-dependent inhibition, reaching 50% at 147 ?L/mL without cytotoxicity. Together with previous literature, these results provide experimental evidence extract, well usefulness cosmetics adjunctive care treatment diseases associated dysregulation signaling cascade.